Thyroid Stimulating Hormone (TSH)

TSHTSH is a hormone synthesized and secreted by the pituitary gland. It stimulates the thyroid gland to secrete the hormones thyroxine (T4) and triiodothyronine (T3) which in turn regulate the release of TSH from the pituitary in a negative feedback loop. TSH is not tightly regulated as it is under control of thyroid releasing hormone (TRH) and feedback from fluctuating systemic thyroid hormones which are subject to binding issues, iodine effects, and many other factors.

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