New Evidence about the Role of Inflammation in Promoting Coronary Atherosclerosis

A recent study published in the journal Atherosclerosis involved investigating epicardial adipose tissue (EAT) pathology, as determined by neoangiogenesis and inflammation, and atherosclerosis in the coronary arteries as determined by computed tomography (CT) imaging. Data included EAT volume, coronary calcium score (CCS), the presence of non-calcified placque (NCP) from CT angiography and measurements of individual macrophages (CD66) and neovessels in six high-powered fields of EAT samples obtained during cardiac surgery (n=45).  Subjects were divided into 3 groups based on CCS (i.e., mild, 0-100; moderate 100-400; severe >400).  Results led the researchers to conclude that inflammation and neoangiogenesis in EAT were significantly correlated with the promotion of coronary atherosclerosis and independently correlated with both NCP and moderate CCS.

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