Researchers for a study published in the February 1, 2014 issue of the American Journal of Cardiology investigated a combination of biomarkers and various other factors (e.g., hypertension, atrial fibrillation, etc.) in patients (n = 706) with known cardiovascular disease to determine their predictive value for cardiovascular events. Elevated levels of galectin-3 and N-terminal fragment of brain natriuretic peptide (NT-proBNP), each independently and significantly (with p-values of 0.007 and 0.004, respectively) predicted an increased incidence of heart failure and death as well as an increased incidence of heart attacks, strokes, and transient ischemic attacks (TIAs).
Reference: Tuñón J, Blanco-Colio L, Cristóbal C, et al. Usefulness of a combination of monocyte chemoattractant protein-1, galectin-3, and N-terminal probrain natriuretic peptide to predict cardiovascular events in patients with coronary artery disease. Am J Cardiol 2014; 113:434-440.