New Research Studies Continue to Link Inflammation with Cardiovascular Disease

In a  very large (n = 10,668), recently published study in Circulation, investigators looked at data from subjects enrolled in the Copenhagen Population Study, the Copenhagen City Heart Study, and the Copenhagen Heart Disease Study combined.  Surprisingly the investigators found a “novel” association between non-fasting remnant lipoproteins with ischemic heart disease (IHD) and inflammation but found that low-density lipoprotein cholesterol elevations, despite the association with IHD, were not associated with inflammation.  Remnant lipoproteins are those that have some cholesterol but are typically rich in triglycerides (e.g., VLDL, IDL, chylomicrons).

Reference: Varbo A, Benn M, Tybjaerg-Hansen A, Nordestgaard BG. Elevated remnant cholesterol causes both low-grade inflammation and ischemic heart disease while low-density lipoprotein cholesterol causes ischemic heart disease without inflammation. Circulation 2013; DOI:10.1161/?CIRCULATIONAHA.113.003008

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