Galectin-3

Galectin-3Galectin-3 is one of the most widely studied galectins, a family of soluble β-galactoside-binding lectins that play regulatory role in inflammation. Galectin-3 affects the synthesis of matrix compounds, such as type I collagen. When cardiac tissue is injured, macrophages infiltrate the tissue and secrete galectin-3, which promotes collagen synthesis and ultimately leads to cardiac fibrosis and adverse cardiac remodeling.

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