Elevated Urinary Microalbumin Creatine Ratio Associated with Worse Outcomes

In another recently published study, this one in the Journal of the American College of Cardiology: Heart Failure, investigators sought to see if there was a relationship between the urinary microalbumin creatinine ratio (UACR) and cardiac structure and/or function in patients with heart failure.  They measured the UACR and did echocardiography studies on 144 subjects with heart failure who also had a preserved ejection fraction.   A number of factors were evaluated including left ventricular mass, right ventricular (RV) systolic function and RV remodeling.  They found that for each doubling of the UACR, there was a statistically significant increase in RV wall thickness of 0.9 mm. and RV systolic functioning was diminished with a 0.56% lower fractional area change.   The authors concluded that the UACR functioned as a prognostic marker that was independently associated with worse outcomes in this patient population.

Reference: Katz DH, Burns JA, Aguilar FG, et al. Albuminurina is independently associated with cardiac remodeling, abnormal right and left ventricular function, and worse outcomes in heart failure with preserved ejection fraction. JACC Heart Fail 2014 Oct 01; [EPub Ahead of Print] 

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